Pursued by the tower's core, a mass of flesh and eyes, the children attempt to jump across a chasm - however, only Six is able to make the jump and Mono is left hanging on to her hand. Mono destroys it and returns Six back to normal, but the tower begins to collapse and the two are forced to flee. Six is later encountered within the Signal Tower, now having been transformed into a massive beast controlled by a music box. The Thin Man suddenly appears and captures Six, forcing Mono to navigate the city and eventually destroy the Thin Man. Traveling even further into the city, they encounter the Viewers, who have been twisted by television signals emitted by the Signal Tower, run by a being called the Thin Man. They then enter a hospital, encountering the mannequin-like Patients and their creator, the obese Doctor who is later killed by the two children when they trap him in an incinerator. The two narrowly escape the Teacher and journey further into the city on the way, Six dons her iconic yellow raincoat for the first time. Six is temporarily taken hostage by the Bullies, but is freed by Mono. They then enter a school, filled with psychotic porcelain Bullies and run by the cruel, long-necked Teacher. The two children then use a door as a raft, sailing across a large body of water and entering the Pale City. While originally hesitant to stick with Mono, Six quickly decides to cooperate with him and the two escape, fleeing the Wilderness in which the Hunter resides and eventually killing him with another rifle. Six is discovered by Mono, Little Nightmares 2's protagonist, in a cage in a cabin owned by a rifle-wielding monster known only as the Hunter. Both the Pretender and the Girl in the Yellow Raincoat fall into the water, and Six is last seen walking down the ledges toward the water. Doing so prompted Six to aid the little girl by dropping a bolder on the Pretender, but it only temporarily knocked her out and broke the ledge that they were standing on.

In Very Little Nightmares, she appears at the end of the game where the Girl in the Yellow Raincoat helped her to escape the Pretender.

The lady little nightmares